✦ LIBER ✦

Naphthalene exposure: Effects on gene expression and proliferation in human cord blood cells

✍ Scribed by Cristina Diodovich; Ilaria Malerba; Gerard Bowe; Francesco Acquati; Marco Giorgio Bianchi; Roberto Taramelli; Dominique Parent-Massin; Laura Gribaldo

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 221 KB
Volume: 17
Category: Article
ISSN: 1095-6670
DOI: 10.1002/jbt.10091

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In this study, the effect of naphthalene on the induction of apoptosis and gene expression profiles in cord blood cells has been evaluated, as well as its activity on the BCL‐2 related protein expression. After 6, 24, and 48 h of exposure to naphthalene (500 μM), a decrease in cell death was observed: the cells became more resistant to the toxicant and capable of surviving after the treatment. A Western blot analysis revealed an overexpression of BCL‐2, c‐JUN, c‐FOS, and RAF‐1 proteins, which are involved in the antiapoptotic response and in the regulation of cell growth, differentiation, and development. Furthermore, macroarray analysis showed that naphthalene modified cord blood gene expression, inducing IL‐8 precursor and T‐cell transcription factor and decreasing the level of RNA‐binding protein FUS/TLS. © 2003 Wiley Periodicals, Inc. J Biochem Mol Toxicol 17:286–294, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.10091

📜 SIMILAR VOLUMES

Gene and protein expressions in human co

Gene and protein expressions in human cord blood cells after exposure to acrylonitrile

✍ Cristina Diodovich; Ilaria Malerba; Daniele Ferrario; Gerard Bowe; Marco Giorgio 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB

## Abstract Acrylonitrile is a very high volume industrial chemical used primarily in the manufacture of plastics and rubber, which displays a pronounced acute toxicity and may be carcinogenic. The damage to the hematopoietic function by acrylonitrile may result from interference with cytokine prod

EFFECTS ON PROTEIN KINASE C AND GENE EXP

EFFECTS ON PROTEIN KINASE C AND GENE EXPRESSION IN A HUMAN MAST CELL LINE, HMC-1, FOLLOWING MICROWAVE EXPOSURE

✍ Charles Harvey; Peter W French 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 477 KB

We used a resonant cavity which delivered a continuous wave exposure at 864.3 MHz at an average specific absorption rate (SAR) of 7 W/kg to determine non-thermal biological effects of microwave exposure. A human mast cell line, HMC-1, was used as the biological target. Cells were given three exposur

EFFECTS OF 3-D CLINO-ROTATION ON GENE EX

EFFECTS OF 3-D CLINO-ROTATION ON GENE EXPRESSION IN HUMAN FIBROBLAST CELLS

✍ Yoshiko Arase; Jun Nomura; Shigeru Sugaya; Katsuo Sugita; Kazuko Kita; Nobuo Suz 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 312 KB

Effects of the flavonoid biochanin A on

Effects of the flavonoid biochanin A on gene expression in primary human hepatocytes and human intestinal cells

✍ Young Jin Moon; Shuzhong Zhang; Daniel A. Brazeau; Marilyn E. Morris 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 391 KB 👁 1 views

## Abstract Biochanin A (BCA), a phytoestrogen present in plant food and herbal products, has been reported to have cancer‐preventive effects that may be mediated, in part, through effects on carcinogen metabolism. Our objective was to examine the effect of BCA on gene expression for drug‐metaboliz

Effects of age and gender on WNT gene ex

Effects of age and gender on WNT gene expression in human bone marrow stromal cells

✍ Longxiang Shen; Shuanhu Zhou; Julie Glowacki 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB 👁 2 views

## Abstract WNT signaling pathways play important roles in the behavior of human bone marrow stromal cells. Although WNT expression has been examined in human bone marrow stromal cells (hMSCs) with limited numbers of subjects or from commercial sources, there are conflicting results on WNT gene exp

TNF-α's effects on proliferation and apo

TNF-α's effects on proliferation and apoptosis in human mesenchymal stem cells depend on RUNX2 expression

✍ Olfa Ghali; Christophe Chauveau; Pierre Hardouin; Odile Broux; Jean-Christophe D 📂 Article 📅 2010 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 369 KB

## Abstract RUNX2 is a bone‐specific transcription factor that plays a critical role in prenatal bone formation and postnatal bone development. It regulates the expression of genes that are important in committing cells into the osteoblast lineage. There is increasing evidence that RUNX2 is involve