Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers

✍ Scribed by Antonella Accardo; Diego Tesauro; Gaetano Mangiapia; Carlo Pedone; Giancarlo Morelli

• Publisher: Wiley (John Wiley & Sons)
• Year: 2007
• Tongue: English
• Weight: 265 KB
• Volume: 88
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.20648

✦ Synopsis

Abstract

The self‐assembling behavior, at physiological pH, of the amphiphile peptide (C18)~2~L5CCK8 in nanostructures is reported. Stable aggregates presenting a critical micellar concentration of 2 × 10^−6^ mol kg^−1^, and characterized by water exposed CCK8 peptide in β‐sheet conformation, are obtained. Small angle neutron scattering experiments are indicative for a 3D structure with dimensions ≥100 nm. AFM images confirm the presence of nanostructures. Fluorescence experiments indicating the sequestration of pyrene, chosen as drug model, and the anticancer Doxorubicin within the nanostructures are reported. © 2006 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 88: 115–121, 2007.

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