Nanoscale Coordination Polymers for Platinum-Based Anticancer Drug Delivery
✍ Scribed by Rieter, William J.; Pott, Kimberly M.; Taylor, Kathryn M. L.; Lin, Wenbin
- Book ID
- 115521094
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 648 KB
- Volume
- 130
- Category
- Article
- ISSN
- 0002-7863
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Platinum-based anticancer agents such as cisplatin and carboplatin are in widespread clinical use but associated with many side effects. Improving the delivery of cytotoxic platinum compounds may lead to reduced side effects and achieve greater efficacy at lower doses. Polymer-based therapeutics hav
## Abstract Triazoles from “click chemistry” are convenient ligands for the formation of platinum complexes bearing combined triazole–amine or triazole–carboxylate moieties. Striking differences in the chelation modes are observed between the two series. One of the triazole–amine platinum complexes