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Click Chelators for Platinum-Based Anticancer Drugs

✍ Scribed by Aurélie Maisonial; Patrycja Serafin; Mounir Traïkia; Eric Debiton; Vincent Théry; David J. Aitken; Pascale Lemoine; Bernard Viossat; Arnaud Gautier

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
263 KB
Volume
2008
Category
Article
ISSN
1434-1948

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✦ Synopsis

Abstract

Triazoles from “click chemistry” are convenient ligands for the formation of platinum complexes bearing combined triazole–amine or triazole–carboxylate moieties. Striking differences in the chelation modes are observed between the two series. One of the triazole–amine platinum complexes exhibits selective cytotoxicity against breast cancer cells lines. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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