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Nanogram scale absolute configurational assignment of ceramides by circular dichroism

✍ Scribed by Hong Jiang; Xuefei Huang; Koji Nakanishi; Nina Berova

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 325 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01581-6

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✦ Synopsis

Ceramides play a central role in cell regulation and a variety of signal transduction pathways. A simple sensitive microscale circular dichroic (CD) method utilizing zinc porphyrins has been developed for assigning the absolute configurations of ceramides at the nanogram scale. The assignment is based on the CD spectra of the bis (zinc porphyrin) derivatives of ceramides with and without the presence of 1,3-diaminopropane. This method can also be applied to various sphingolipids after enzymatic cleavage to ceramides.

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