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Determination of the Absolute Configuration of (−)-Mirtazapine by Vibrational Circular Dichroism

✍ Scribed by Teresa B. Freedman; Rina K. Dukor; Peter J. C. M. van Hoof; Edwin R. Kellenbach; Laurence A. Nafie

Publisher
John Wiley and Sons
Year
2002
Tongue
German
Weight
92 KB
Volume
85
Category
Article
ISSN
0018-019X

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✦ Synopsis

The absolute configuration of the (À)-enantiomer of mirtazapine was determined by means of vibrational circular dichroism (VCD). The observed VCD of (À)-mirtazapine showed excellent correlation with the calculated VCD of the (R)-enantiomer. This is in agreement with the absolute configuration as determined by independent synthesis starting from (R)-phenylglycine.

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