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Nance-Horan syndrome: linkage analysis in 4 families refines localization in Xp22.31–p22.13 region

✍ Scribed by A. Toutain; Nathalie Ronce; Benoît Dessay; Laura Robb; Christine Francannet; Martine Le Merrer; Marie-Louise Briard; Josseline Kaplan; Claude Moraine


Book ID
106136567
Publisher
Springer
Year
1997
Tongue
English
Weight
76 KB
Volume
99
Category
Article
ISSN
0340-6717

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The Opitz GBBB syndrome (OS) is characterized in part by widely spaced inner ocular canthi and hypospadias. Recently, linkage analysis showed that the gene for the X-linked form to be located in an 18 cM region spanning Xp22. We have now conducted linkage analysis in a family previously published as