𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Linkage analysis in a family with the Opitz GBBB syndrome refines the location of the gene in Xp22 to a 4 cM region.

✍ Scribed by May, Melanie; Huston, Sara; Wilroy, R. Sid; Schwartz, Charles

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
486 KB
Volume
68
Category
Article
ISSN
0148-7299

No coin nor oath required. For personal study only.

✦ Synopsis

The Opitz GBBB syndrome (OS) is characterized in part by widely spaced inner ocular canthi and hypospadias. Recently, linkage analysis showed that the gene for the X-linked form to be located in an 18 cM region spanning Xp22. We have now conducted linkage analysis in a family previously published as having the BBB syndrome and found tight linkage to DXS7104 (Z = 3.3, theta = 0.0). Our data narrows the candidate region to 4 cM and should facilitate the identification and characterization of one of the genes involved in midline development.

📜 SIMILAR VOLUMES

Genetic linkage of region containing the
Genetic linkage of region containing the CREB1 gene to depressive disorders in families with recurrent, early-onset, major depression: A re-analysis and confirmation of sex-specific effect
✍ Brion S. Maher; Hugh B. Hughes III; Wendy N. Zubenko; George S. Zubenko 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 113 KB 👁 2 views

## Abstract A previously published model‐free linkage analysis of chromosome 2q33–35, highlighted by previous case–control studies and supported by within‐family analyses employing the transmission disequilibrium test, revealed evidence of sex‐specific linkage of the __CREB1__‐containing region of