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Naloxone-induced electrographic seizures in the primate

✍ Scribed by E. W. Snyder; D. E. Shearer; E. C. Beck; R. E. Dustman

Publisher
Springer
Year
1980
Tongue
English
Weight
423 KB
Volume
67
Category
Article
ISSN
0033-3158

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We assessed the effects of N(omega)-nitro-L-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), on behavioral and electrographic seizures elicited in mice by convulsant doses of kainate. In Expt. 1, L-NAME dose-dependently potentiated the convulsant effects of kainate (44 mg