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Naked DNA injection for liver metastases treatment in rats

✍ Scribed by Patrick Baqué; Valérie Pierrefite-Carle; Adolfo Gavelli; Nicole Brossette; Daniel Benchimol; André Bourgeon; Pascal Staccini; Marie-Christine Saint-Paul; Bernard Rossi


Book ID
111721826
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
210 KB
Volume
35
Category
Article
ISSN
0270-9139

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## Background: High levels of foreign gene expression in mouse hepatocytes can be achieved by rapid tail vein injection of a large volume of a naked dna solution, the 'hydrodynamics-based procedure'. rats are more tolerant of the frequent phlebotomies required for monitoring blood parameters than m