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(NA++K+)-ATPase of Duchenne muscular dystrophy erythrocyte ghosts

✍ Scribed by Terry W. Pearson

Book ID
118938578
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
340 KB
Volume
22
Category
Article
ISSN
0024-3205

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Erythrocytes from patients with Duchenne muscular dystrophy (DMD) were studied in relation to the extracellular calcium ion concentration. The shape of fresh erythrocytes in DMD was normal and not affected by Ca++. When DMD erythrocytes were stored in buffer solution with Ca++, however, the rate of

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Erythrocyte ghost (Na+ + K+) ATPase activity was studied in mice with hereditary muscular dystrophy (strain C 57 BL 6J/dy) and appropriate controls. No difference was observed in the enzymatic activity between dystrophic and any of the healthy genotypes. Ouabain 5 mM and 0.1 mM inhibited the enzymat