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Nad(p)+-nad(p)h models. 50. Stereo-controlled reduction of methyl 2-oxo-3-methylpentanoate

✍ Scribed by Atsuyoshi Ohno; Hee Lee Joung; Tsuneo Yasuma; Shinzaburo Oka


Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
214 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis


Racemic and optically active title compound was reduced with chiral and achiral NAD(P)H models.

The composition of diastereomers in the product was determined and the steric relationship is discussed.


📜 SIMILAR VOLUMES


NAD(P)H models XV. Reduction of Δ4-3-ket
✍ Ronald A. Case; Upendra K. Pandit 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 607 KB

## Abstract Pyrrolidinium salts derived from a series of 17‐substituted Δ^4^‐3‐ketosteroids are reduced by 1‐benzyl‐1,4‐dihydronicotinamide (BNAH) and 2,6‐dimethyl‐3,5‐diethoxycarbonyl‐1,4‐dihydropyridine (Hantzsch ester, 1 eq.) to the corresponding isomeric 5α‐ and 5β‐enamines which hydrolyse to t