Nabumetone inhibits experimental colon carcinogenesis: Modulation of cyclin D1
โ Scribed by Roy, Hemant Kumar; Karolski, William J.; Ratashak, Anne; Smyrk, Thomas C.
- Book ID
- 124119674
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 185 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0016-5085
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Use of non-steroidal anti-inflammatory drugs (NSAIDs) for chemoprevention of colon cancer has been hindered by their potential gastro-intestinal toxicity. Nabumetone, which is approximately 10 to 36 times safer than conventional NSAIDs, was evaluated in 2 models of experimental colon carcinogenesis.