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Nabumetone inhibits experimental colon carcinogenesis: Modulation of cyclin D1

โœ Scribed by Roy, Hemant Kumar; Karolski, William J.; Ratashak, Anne; Smyrk, Thomas C.


Book ID
124119674
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
185 KB
Volume
120
Category
Article
ISSN
0016-5085

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Use of non-steroidal anti-inflammatory drugs (NSAIDs) for chemoprevention of colon cancer has been hindered by their potential gastro-intestinal toxicity. Nabumetone, which is approximately 10 to 36 times safer than conventional NSAIDs, was evaluated in 2 models of experimental colon carcinogenesis.