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N-substituted cyclopropylamines as inhibitors of MAO-A and -B forms

✍ Scribed by Dennis L. Murphy; Cynthia H. Donnelly; Elliott Richelson; Ray W. Fuller


Book ID
115774277
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
242 KB
Volume
27
Category
Article
ISSN
0006-2952

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A series of N-substituted-3-[(2 0 -hydroxy-4 0 -prenyloxy)-phenyl]-5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure-activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine at