Synthesis and pharmacological evaluation
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Hiroshi Enomoto; Ayako Sawa; Hiroshi Suhara; Noriyoshi Yamamoto; Hiroyuki Inoue;
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Article
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2010
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Elsevier Science
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English
⚖ 335 KB
A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-a