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N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxo-acetamide: a high affinity 5-HT3 receptor partial agonist

✍ Scribed by R.D. Clark; J.M. Muchowski; K.K. Weinhardt; M.P. Dillon; C-H. Lee; K.R. Bley; D.W. Bonhaus; E.H.F. Wong; R.M. Eglen

Book ID
103983030
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
195 KB
Volume
5
Category
Article
ISSN
0960-894X

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✦ Synopsis

The enantiomers of the indolyl-2-oxoacetamide 5 were found to have 5-HT3 receptor partial agonist activity with (R)-5 having higher potency than (S)-5.

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The molecular structure of the title compound, C~39~H~62~N~2~O~5~Si~2~, obtained as an unexpected side product, was determined in the course of our studies on the synthesis of __N__-triisopropyl-1__H__-indol-3-yl derivatives. Interestingly, although the triisopropylsilyl group was intended as a temp