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N-oxide mediated oxidation of the C6 position of an angucyclinone ring system

✍ Scribed by Vincent A. Boyd; Joseph Reibenspies; Gary A. Sulikowski


Book ID
103409812
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
188 KB
Volume
36
Category
Article
ISSN
0040-4039

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The c~-diazoester I in the presence of catalytic Rh2(OAc)4 was converted to the carbapenam 2. The synthesis of 1 and a proposed mechanism are described. A variety of strategies currently exists in the literature for the synthesis of bicyclic 13-1actams.