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Synthesis of the carbapenam ring system via carbene mediated rearrangement of an n-benzyloxy-β-lactam

✍ Scribed by Matthew A. Williams; Marvin J. Miller

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
161 KB
Volume
31
Category
Article
ISSN
0040-4039

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✦ Synopsis

The c~-diazoester I in the presence of catalytic Rh2(OAc)4 was converted to the carbapenam 2. The synthesis of 1 and a proposed mechanism are described.

A variety of strategies currently exists in the literature for the synthesis of bicyclic 13-1actams.

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