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N-MYC AMPLIFICATION IN MALIGNANT ASTROCYTOMA

✍ Scribed by Garson, J.A.; Mcintyre, P.G.; Kemshead, J.T.

Book ID: 123352991
Publisher: The Lancet
Year: 1985
Tongue: English
Weight: 471 KB
Volume: 326
Category: Article
ISSN: 0140-6736
DOI: 10.1016/S0140-6736(85)92950-2

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## Abstract Loss of heterozygosity (LOH) for chromosome arms 9p, 10p, 10q, and 17p and amplification of the epidermal growth factor receptor (__EGFR__) gene have been identified as frequent genetic changes in malignant astrocytomas. We have found amplification of the anonymous marker D17S67 on chro