N-methylation of peptides
โ Scribed by Marino, G.; Valente, L.; Johnstone, R. A. W.; Mohammedi-Tabrizi, F.; Sodini, G. C.
- Book ID
- 121365230
- Publisher
- The Royal Society of Chemistry
- Year
- 1972
- Tongue
- English
- Weight
- 182 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0022-4936
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๐ SIMILAR VOLUMES
In N-methyl amino acids, the hydrogen of the N-H group is replaced with a bulky methyl group. While this change is expected to destabilize helical structures, the amount of destabilization is not known. Here the N-methyl group is placed into several positions of the helical peptides, acetyl-WGG( EAA
Peptides containing N(alpha)-methylamino acids exhibit interesting therapeutic profiles and are increasingly recognized as potentially useful therapeutics. Unfortunately, their synthesis is hampered by the high price and nonavailability of many N(alpha)-methylamino acids. An efficient and practical