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N -Methyl- d -aspartic Acid Receptor Agonists: Resolution, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 2-Amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic Acid

✍ Scribed by Madsen, Ulf; Frydenvang, Karla; Ebert, Bjarke; Johansen, Tommy N.; Brehm, Lotte; Krogsgaard-Larsen, Povl


Book ID
126094816
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
379 KB
Volume
39
Category
Article
ISSN
0022-2623

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Excitatory amino acid receptor antagonis
✍ Tommy N. Johansen; Karla Frydenvang; Bjarke Ebert; Ulf Madsen; Povl Krogsgaard-L πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 228 KB πŸ‘ 2 views

We have previously shown that (RS)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA) is an antagonist at N-methyl-D-aspartic acid (NMDA) and (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors. We have now resolved ATAA via diastereomeric salt formation us