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N-methoxy-n-methylamides as effective acylating agents

✍ Scribed by Steven Nahm; Steven M. Weinreb

Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
176 KB
Volume
22
Category
Article
ISSN
0040-4039

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✦ Synopsis

Readily preparable N-methoxy-N-methylamides couple in good yields with Grignard and organolithium reagents to produce ketones, and are reduced with hydrides to afford aldehydes.

πŸ“œ SIMILAR VOLUMES

A new synthesis of Ξ±,Ξ²-unsaturated N-met
A new synthesis of Ξ±,Ξ²-unsaturated N-methoxy-N-methylamides
✍ Chantal Beney; AhcΓ¨ne Boumendjel; Anne-Marie Mariotte πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 110 KB

phenyl(N-methoxy-N-methylcarbamoylmethyl)sulfoxide 1 is prepared in 2 steps starting from N-methoxy-N-methyichloroacetamide and thiophenol. Reagent 1 is useful for homologation of alkyl halides to ct,l~-unsaturated N-methoxy-N-methylamide compounds.