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N -Isopropylsulfinylimines as Useful Intermediates in the Synthesis of Chiral Amines: Expeditive Asymmetric Synthesis of the Calcimimetic (+)-NPS R-568

✍ Scribed by Fernández, Inmaculada; Valdivia, Victoria; Khiar, Noureddine


Book ID
127294835
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
92 KB
Volume
73
Category
Article
ISSN
0022-3263

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Chemoenzymatic synthesis of the calcimim
✍ Kiwon Han; Yunwoong Kim; Jaiwook Park; Mahn-Joo Kim 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 188 KB

A practical and efficient procedure for the synthesis of a potent calcimimetic (+)-NPS R-568 was developed. This procedure includes as the key step the asymmetric reductive acylation of a ketoxime intermediate catalyzed by a Pd nanocatalyst and a lipase in combination. The target compound was prepar