Chemoenzymatic synthesis of the calcimim
✍
Kiwon Han; Yunwoong Kim; Jaiwook Park; Mahn-Joo Kim
📂
Article
📅
2010
🏛
Elsevier Science
🌐
French
⚖ 188 KB
A practical and efficient procedure for the synthesis of a potent calcimimetic (+)-NPS R-568 was developed. This procedure includes as the key step the asymmetric reductive acylation of a ketoxime intermediate catalyzed by a Pd nanocatalyst and a lipase in combination. The target compound was prepar