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Chemoenzymatic synthesis of the calcimimetics (+)-NPS R-568 via asymmetric reductive acylation of ketoxime intermediate

✍ Scribed by Kiwon Han; Yunwoong Kim; Jaiwook Park; Mahn-Joo Kim

Book ID: 104097791
Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 188 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.04.121

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✦ Synopsis

A practical and efficient procedure for the synthesis of a potent calcimimetic (+)-NPS R-568 was developed. This procedure includes as the key step the asymmetric reductive acylation of a ketoxime intermediate catalyzed by a Pd nanocatalyst and a lipase in combination. The target compound was prepared from commercially available 3 0 -methoxyacetophenone via five steps in overall 63% yield.

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