๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

N-hydroxymethyl derivatives of nitrogen heterocycles as possible prodrugs I: N-hydroxymethylation of uracils

โœ Scribed by Padam C. Bansal; Ian H. Pitman; Josiah N. S. Tam; Mathias Mertes; James J. Kaminski

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
563 KB
Volume
70
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Aqueous degradation of N-(hydroxymethyl)
Aqueous degradation of N-(hydroxymethyl)-phthalimide in the presence of specific and general bases. Kinetic assessment of N-hydroxymethyl derivatives of nitrogen heterocycles as possible prodrugs
โœ M.Niyaz Khan ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 488 KB

The conversion of N-(hydroxymethyl)phthalimide (NHPH) to phthalimide could not be detected within 300 s at pH 9.0, whereas in 0.18 M NaOH complete conversion of NHPH to phthalimide was observed within 50 s. In the presence of 0.2-0.4 M 1,4-diazabicyclo[2.2.2]octane buffer solutions (pH 9.30-9.54), 4

Rate of formation of N-(hydroxymethyl)be
Rate of formation of N-(hydroxymethyl)benzamide derivatives in water as a function of pH and their equilibrium constants
โœ Ramana V. Ankem; John L. Murphy; Richard W. Nagorski ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 181 KB

The third-order rate constants for the pH-dependent formation of the carbinolamides generated from the reaction of formaldehyde and benzamide, 4-chloro, 4-nitro, 4-methyl and 4-methoxybenzamide, are reported. The acid-catalyzed reaction was found to occur via rate-limiting proton transfer, whereas t