N-(carbobenzyloxy)isatin: A slow binding α-keto lactam inhibitor of α-chymotrypsin

✍ Scribed by Ramaswamy A. Iyer; Patrick E. Hanna

• Book ID: 103982765
• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 170 KB
• Volume: 5
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(94)00464-q

✦ Synopsis

The N-carbobenzyloxy derivative of 2,3-dioxindole (N-Cbz-isatin) (1) has been synthesized and shown to be a slow binding inhibitor of chymotrypsin. Compound 1 does not inhibit porcine pancreatic elastase. The N-tert-butoxycarbonyl derivative of 2,3-dioxindole ( 2) is a weak inhibitor of chymotrypsin and does not inhibit porcine pancreatic elastase.