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ChemInform Abstract: N-(Carbobenzyloxy)isatin: A Slow Binding α-Keto Lactam Inhibitor of α-Chymotrypsin.

✍ Scribed by R. A. IYER; P. E. HANNA


Book ID
112022058
Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
26
Category
Article
ISSN
0931-7597

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N-(carbobenzyloxy)isatin: A slow binding
✍ Ramaswamy A. Iyer; Patrick E. Hanna 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 170 KB

The N-carbobenzyloxy derivative of 2,3-dioxindole (N-Cbz-isatin) (1) has been synthesized and shown to be a slow binding inhibitor of chymotrypsin. Compound 1 does not inhibit porcine pancreatic elastase. The N-tert-butoxycarbonyl derivative of 2,3-dioxindole ( 2) is a weak inhibitor of chymotrypsin