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N-Alkylation of Diethyl Acetamidomalonate: Synthesis of Constrained Amino Acid Derivatives by Ring-Closing Metathesis.

โœ Scribed by Sambasivarao Kotha; Kuldeep Singh


Publisher
John Wiley and Sons
Year
2005
Weight
26 KB
Volume
36
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis of Constr
โœ S. KOTHA; N. SREENIVASACHARY; E. BRAHMACHARY ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 36 KB

Synthesis of Constrained ฮฑ-Amino Acid Derivatives via Enyne Metathesis Reaction. -Ring-closing metathesis of the enyne (VI), prepared following an optimized approach, in the presence of Grubb's catalyst gives the vinylcyclopentene (VII). The latter undergoes Diels-Alder reaction with the appropriat