ChemInform Abstract: Synthesis of Constrained α-Amino Acid Derivatives via Enyne Metathesis Reaction.

✍ Scribed by S. KOTHA; N. SREENIVASACHARY; E. BRAHMACHARY

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 36 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199830112

✦ Synopsis

Synthesis of Constrained α-Amino Acid Derivatives via Enyne Metathesis Reaction.

-Ring-closing metathesis of the enyne (VI), prepared following an optimized approach, in the presence of Grubb's catalyst gives the vinylcyclopentene (VII). The latter undergoes Diels-Alder reaction with the appropriate dienophiles. Following DDQ-oxidation of the [4 + 2] cycloadducts leads to constrained α-amino acid derivatives. -(KOTHA, S.;