## Abstract As a result of difficulties with the synthesis of pure O‐(m)ethoxycarbonylferulyl chloride, N‐ferulylglycyl‐L‐phenylalanine (XVI) was previously prepared by a mixed anhydride method. However, due to the fact that analogous N‐acyl‐dipeptides were easily obtained by the acid chloride meth
N-acylamino acids and peptides I. The synthesis of N-feruloylamino acids
✍ Scribed by H. De Pooter; Haider Ali; C. F. van Sumere
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2010
- Weight
- 580 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0037-9646
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✦ Synopsis
Abstract
Procedures for the preparation of N‐feruloylglycine (II), ‐DL‐alanine (XX), ‐DL‐valine (XXII) and ‐L‐leucine (XXIV) by classical methods are proposed and compared. The spectral characteristics and Rf‐values of the substances are included. The compounds were synthesized because N‐feruloylamino acids were required as test substances during an investigation in connection with the expected presence of N‐feruloylproteins in barley [1, 2, 3].
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## Abstract N‐(Feruloyl‐2‐^14^C)‐glycine‐2‐^3^H (IX) was obtained with an acceptable yield (43%) starting from O‐methoxycarbonyl‐ferulic acid‐2‐^14^C (IV) and glycine‐2‐^3^H ethyl ester (VI). The latter two compounds were first condensed into N‐(O‐methoxycarbonyl‐feruloyl‐2‐^14^C)‐glycine ‐2‐^3^H e