N-Acyl-β-phenethylamines, and a New Isoquinoline Synthesis
✍ Scribed by Ritter, John J.; Murphy, Francis X.
- Book ID
- 118268762
- Publisher
- American Chemical Society
- Year
- 1952
- Tongue
- English
- Weight
- 418 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0002-7863
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received in UK for pablication 4 M~y 1978) y-and e-oxygenated acrylates and enones are important features of many natural products, including macrocyclic antibiotics such as pyrenophorin (i) and brefeldin A (2),cytochalasin B, and the prostaglandin family. While multiple step processes for the prepa
Amide bonds are formed readily under mild conditions by the reaction of N-silylamines with the hydrolytically stable acyl fluorides.
In previous papers, l-3 we reported the synthesis of a,S-unsaturated N-acyla-amino acid ester (1) by the condensation of ethyl a-oxocarboxylate with amide or by the treatment of N-acetoxy-N-acyl-a-amino acid ester with Et3N. Up to date,