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N-Acyl-4,5-dihydro-4,4-dimethyl-N-methyl-2-thiazolamine as a chemoselective acylating agent

✍ Scribed by Taek Hyeon Kim; Garp-Yeol Yang

Book ID
104252535
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
354 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

2-Methylamino-2-thiazoline reacted with alkyl acyl halides to produce N-acyl-2-methylamino-2-thiazolines, exoacylated product regioselectively, which were found to be highly chemoselective acylating agents for primary amine in the presence of secondary amine and for the less sterically hindered of two different primary amines.

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Studies on Development of Sufficiently Chemoselective N-Acylation Reagents: N-Acyl-N-(2,3,4,5,6-pentafluorophenyl)methanesulfonamides
✍ Kazuhiro Kondo; Erika Sekimoto; Junko Nakao; Yasuoki Murakami 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 234 KB

AbstractÐA variety of storable N-acyl-N-(2,3,4,5,6-penta¯uorophenyl)methanesulfonamides (4a±e) prepared from N-2,3,4,5,6-penta¯uorophenylmethanesulfonamide (3), have been developed after systematic research on the structure±reactivity relationship and were found to serve as N-acylation reagents exhi