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N-acetylation Pharmacogenetics: A Gene Deletion Causes Absence of Arylamine N-acetyltransferase in Liver of Slow Acetylator Rabbits

✍ Scribed by Martin Blum, Denis M. Grant, Anne Demierre and Urs A. Meyer

Book ID: 123637585
Publisher: National Academy of Sciences
Year: 1989
Tongue: English
Weight: 966 KB
Volume: 86
Category: Article
ISSN: 0027-8424
DOI: 10.2307/35121

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## Abstract __N__‐acetyltransferase 1 (NAT1) and 2 (NAT2) enzymes catalyzing both deactivation (__N__‐acetylation) and activation (__O__‐acetylation) of arylamine carcinogens such as 4‐aminobiphenyl (ABP) were investigated in a Syrian hamster model congenic at the __NAT__2 locus. NAT2 catalytic act