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N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs

✍ Scribed by Anjan Nan; N.P.Dhammika Nanayakkara; Larry A Walker; Vanessa Yardley; Simon L Croft; Hamidreza Ghandehari


Book ID
114161442
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
161 KB
Volume
77
Category
Article
ISSN
0168-3659

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## Abstract Amphiphilic block copolymers based on HPMA and ε‐CL were synthesized by ring‐opening polymerization of ε‐CL followed by RAFT polymerization of HPMA. A copolymer composed of 34 kDa PHPMA and 8.5 kDa PCL associated into micelles with CMC of 5.4 µg · mL^−1^. A novel retinoid, 3‐Cl‐AHPC‐OMe