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Synthesis and Characterization of Poly(ε-caprolactone)-block-poly[N-(2-hydroxypropyl)methacrylamide] Micelles for Drug Delivery

✍ Scribed by Stefan G. Krimmer; Huaizhong Pan; Jihua Liu; Jiyuan Yang; Jindřich Kopeček

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
747 KB
Volume
11
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Amphiphilic block copolymers based on HPMA and ε‐CL were synthesized by ring‐opening polymerization of ε‐CL followed by RAFT polymerization of HPMA. A copolymer composed of 34 kDa PHPMA and 8.5 kDa PCL associated into micelles with CMC of 5.4 µg · mL^−1^. A novel retinoid, 3‐Cl‐AHPC‐OMe, was incorporated into micelles with 25 wt.‐% loading by dialysis method. The effective diameter of drug loading micelles was 117 nm. Incubation of micelles in PBS at 37 °C indicated 86 wt.‐% of the drug was released after 96 h. Cytotoxicity studies performed with C4‐2 prostate cancer cells showed the IC~50~ dose was 1.96 µM after 72 h of incubation, whereas the micelles without drug showed no cytotoxicity. magnified image

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