𝔖 Bobbio Scriptorium
✦   LIBER   ✦

(N-[11C]-Methyl)doxepin: Synthesis of a radiotracer for studying the histamine H-1 receptor

✍ Scribed by Hayden T. Ravert; Robert F. Dannals; Alan A. Wilson; Henry N. Wagner Jr.

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
208 KB
Volume
31
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Doxepin (3‐dibenz [b,e] oxepin ‐ 11(6H) ‐ ylidene ‐ N,N ‐ dimethyl ‐ 1 ‐ propanamine), a potent H~1~ histamine antagonist, was labeled with ^11^C‐iodomethane by N‐alkylation of normethyldoxepin. The synthesis, purification, and formulation were performed in approximately 20 minutes with an average specific activity of 1630 mCi/μmol (EOS).

📜 SIMILAR VOLUMES

Synthesis of a radiotracer for studying
Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β-carbomethoxy-3β-(4-fluorophenyl)-[N-11C-methyl]tropane ([11C]CFT or [11C]WIN-35,428)
✍ Robert F. Dannals; John L. Neumeyer; Richard A. Milius; Hayden T. Ravert; Alan A 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 320 KB

## Abstract 2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐^11^C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [^11^C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the rad

Synthesis of N-(11C) methyl, N-(methyl-1
Synthesis of N-(11C) methyl, N-(methyl-1 propyl), (chloro-2 phenyl)-1 isoquinoleine carboxamide-3 (PK 11195): A new ligand for peripheral benzodiazepine receptors
✍ R Camsonne; C Crouzel; D Comar; M Mazière; C Prenant; J Sastre; Ma Moulin; A Syr 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 219 KB

N-(llC) methyl, N-(methyl-1 propyl), (chloro-2 phenylj-1 isoquinoleine carboxamide-3 (PK 11195) o r ( l l C ) MPCI was synthetized in a short time (45 min) and high s p e c i f i c a c t i v i t y (769 Ci/mmol) for the positron emission tomography of peripheral benzodiazepine receptors in heart, kid

Synthesis of a radiotracer for studying
Synthesis of a radiotracer for studying σ receptors in vivo using PET: (+)-N-[11C]-benzyl-N-normetazocine (1S, 5S,9S-(+)-cis-2-[11C]-2′-hydroxy-5,9-dimethyl-6,7-benzomorphan)
✍ John L. Musachio; William B. Mathews; Hayden T. Ravert; F. Ivy Carroll; Robert F 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 440 KB

## Abstract (+)‐__N__‐[^11^C]‐Benzyl‐__N__‐normetazocine (1__S__,5__S__,9__S__‐(+)‐__cis__‐2‐[^11^C]‐benzyl‐2′‐hydroxy‐5,9‐dimethyl‐6,7‐benzomorphan), a potent and selective ligand for the σ receptor, was prepared by N‐benzylation of (+)‐__cis__‐__N__‐normetazocine with [α‐^11^C]‐benzyl iodide in e