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Myopathic Mutations Affect Differently the Inactivation of the Two Gating Modes of Sodium Channels

✍ Scribed by Oscar Moran; Mario Nizzari; Franco Conti


Book ID
110225086
Publisher
Springer US
Year
1999
Tongue
English
Weight
493 KB
Volume
31
Category
Article
ISSN
0145-479X

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## Abstract The sodium channel gene __Scn8a__ encodes the channel Na~V~1.6, which is widely distributed in the central and peripheral nervous system. Na~V~1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse __Scn8a__ result in neurological disorders includi