## Abstract The __MYH__ gene has recently been shown to be associated with a recessive form of colorectal adenomatous polyposis. Two common mutations in the __MYH__ gene have been identified that lend themselves to rapid screening. We have examined a series of 302 individuals comprising 120 control
MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps
β Scribed by Liang Wang; Linnea M. Baudhuin; Lisa A. Boardman; Kelle J. Steenblock; Gloria M. Petersen; Kevin C. Halling; Amy J. French; Ruth A. Johnson; Lawrence J. Burgart; Kari Rabe; Noralane M. Lindor; Stephen N. Thibodeau
- Book ID
- 119757782
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 186 KB
- Volume
- 127
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Biallelic germline mutations in the base excision repair gene __MYH__ have been reported in patients with multiple colorectal adenomas and cancer and in sporadic FAP patients not showing a detectable __APC__ germline mutation. In this study, the prevalence of the common Y165C and G382D