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Myelofibrosis, JAK2 inhibitors and erythropoiesis

✍ Scribed by Vainchenker, W; Favale, F


Book ID
120399890
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
339 KB
Volume
27
Category
Article
ISSN
0887-6924

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JAK2-inhibitors rapidly reduce spleen enlargement and clinical symptoms in persons with myelofibrosis but have little, if any, effect on the WBC, anemia, decreased platelets or bone marrow fibrosis. Also, JAK2-inhibitors are active in persons with and without the JAK2-mutation. Based on these and ot