Myelination in the absence of myelin-associated glycoprotein
β Scribed by Li, Chumei; Tropak, Michael B.; Gerlai, Robert; Clapoff, Susan; Abramow-Newerly, Wanda; Trapp, Bruce; Peterson, Alan; Roder, John
- Book ID
- 109789004
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 700 KB
- Volume
- 369
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/369747a0
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The nucleotide sequence for human myelin-associated glycoprotein (MAG) and its deduced amino acid sequence, obtained by analysis of two overlapping cDNA clones isolated from a human brain cDNA li- brary, is presented and compared to that reported for rat MAG. The sequence provides an open reading f
## Abstract Myelinβassociated glycoprotein (MAG) is expressed on the innermost myelin membrane wrap, directly apposed to the axon surface. Although it is not required for myelination, MAG enhances longβterm axonβmyelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskele
Two mouse monoclonal antiidiotypic antibodies that react with human monoclonal IgM antibodies with specificity for myelin-associated glycoprotein (MAG) have been used to study the immunological specificity of the reported cross-reactions involving the anti-MAG IgM. Both of the antiidiotypic antibodi