Previous studies from our laboratory showed the development of circulating T lymphocytes sensitized to myelin basic protein (MBP) in guinea pigs challenged with MBP. Also, lymphocytes sensitized to MBP were found in patients with multiple sclerosis (MS). In this report, we describe the kinetics of M
✦ LIBER ✦
Myelin basic protein–specific T lymphocytes in multiple sclerosis and controls: Precursor frequency, fine specificity, and cytotoxicity
✍ Scribed by Dr. Zhang Jingwu; Robert Medaer; George A. Hashim; Ying Chin; Ella van den Berg-Loonen; Jef C. M. Raus
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 923 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0364-5134
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## Abstract T cell reactivity to candidate myelin autoantigens, such as myelin basic protein (MBP), may play an important role in the pathogenesis of multiple sclerosis (MS). Although MBP‐reactive T cellshave been found to undergo __in vivo__ activation in patients with MS, their true precursor fre
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