Myelin basic protein intramolecular spreading without disease progression in a patient with multiple sclerosis
β Scribed by G. Ristori; F. Giubilei; D. Giunti; A. Perna; C. Gasperini; C. Buttinelli; M. Salvetti; A. Uccelli
- Book ID
- 114137209
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 114 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0165-5728
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π SIMILAR VOLUMES
Cerebrospinal fluid (CSF) from 105 patients was analyzed by radioimmunoassay for the presence of material cross-reactive with peptide 89-169 of bovine myelin basic protein (BP). In a group of 72 multiple sclerosis patients, 52 showed higher BP content than the control group, i.e. more than 2 ng/ml C
Previous studies from our laboratory showed the development of circulating T lymphocytes sensitized to myelin basic protein (MBP) in guinea pigs challenged with MBP. Also, lymphocytes sensitized to MBP were found in patients with multiple sclerosis (MS). In this report, we describe the kinetics of M