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MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma

✍ Scribed by Manohar, Chitra F; Bray, James A; Salwen, Helen R; Madafiglio, Janice; Cheng, Andy; Flemming, Claudia; Marshall, Glenn M; Norris, Murray D; Haber, Michelle; Cohn, Susan L

Book ID: 110068232
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 281 KB
Volume: 23
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1207151

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## Abstract The CD44 adhesion receptor is silenced in highly malignant neuroblastomas (NBs) with __MYCN__ amplification. Because its functional expression is associated with decreased tumorigenic properties, __CD44__ behaves as a tumor suppressor gene in NB and other cancers. Given that the precise