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Evidence that the MYCN oncogene regulates MRP gene expression in neuroblastoma

✍ Scribed by M.D Norris; S.B Bordow; P.S Haber; G.M Marshall; M Kavallaris; J Madafiglio; S.L Cohn; H Salwen; M.L Schmidt; D.R Hipfner; S.P.C Cole; R.G Deeley; M Haber


Book ID
117663993
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
255 KB
Volume
33
Category
Article
ISSN
0959-8049

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MYCN amplification in neuroblastomas is strongly associated with advanced stages of disease and a poor prognosis. We have recently defined a 130 kb core region of the MYCN amplicon that is consistently amplified in neuroblastomas. However, it has been argued that other expressed sequences were coamp