✦ LIBER ✦

Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1

✍ Scribed by Tiziana DeAngelis; Andrea Morrione; Renato Baserga

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 197 KB
Volume: 224
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.22164

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✦ Synopsis

Abstract

The insulin receptor substrate‐1 (IRS‐1) and c‐met, the receptor for the hepatocyte growth factor (HGF) co‐immuno‐precipitate from lysates treated with the respective antibodies. The interaction between IRS‐1 and c‐met requires a tyrosyl phosphorylated IRS‐1 and results in reciprocal down‐regulation. IRS‐1 inhibits cell motility, while the activated c‐met promotes it. These and other results suggest an explanation for reports in the literature indicating that c‐met levels are high and IRS‐1 levels are low in human cancer metastases. J. Cell. Physiol. 224: 658–663, 2010. © 2010 Wiley‐Liss, Inc.

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