Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis B
✍ Scribed by A. Erhardt; U. Reineke; D. Blondin; W.H. Gerlich; O. Adams; T. Heintges; C. Niederau; D. Häussinger
- Book ID
- 119525805
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 97 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0168-8278
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## Abstract Therapy for chronic hepatitis B with interferon‐α (IFN) may result in viral clearance and hepatitis B e seroconversion in 30–40% of patients. It is still unclear whether viral genetic variability influences response rates. However, certain core promoter mutations were recently associate
The core promoter region of hepatitis B virus genomes regulates transcription of the precore and pregenomic mRNAs encoding hepatitis B e antigen (HBeAg) and core antigen that contain target epitopes for cytotoxic T lymphocytes. The prevalence and clinical significance of mutations in this region wer