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Mutations increased overexpression ofNotch1 in T-cell acute lymphoblastic leukemia

✍ Scribed by Chunlan Lin, Haitao Zheng, Chunyan Wang, Lijian Yang, Shaohua Chen, Bo Li, Yubing Zhou, Huo Tan, Yangqiu Li


Book ID
119900715
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
287 KB
Volume
12
Category
Article
ISSN
1475-2867

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## Abstract T‐cell acute lymphoblastic leukemia (T‐ALL) is the result of multiple oncogenic insults of thymocytes. Recently, new __ABL1__ fusion genes have been identified that provide proliferation and survival advantage to lymphoblasts. These are the __NUP214‐ABL1__ fusion gene, on amplified epis