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Mutations including the promoter region of myocilin/TIGR gene

✍ Scribed by Saura, Maria; Cabana, Montse; Ayuso, Carmen; Valverde, Diana


Book ID
110025704
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
73 KB
Volume
13
Category
Article
ISSN
1018-4813

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Inactivation of the human retinoblastoma tumor-suppressor gene (RB1; MIM # 180200) is usually caused by mutations in the coding region, but mutations in the promoter region can also affect RB1 gene expression. A 103-bp deletion in the promoter region in a prostate cancer was reported to abrogate RB1