Mutations in Transforming Growth Factor-β Receptor Type II Cause Familial Thoracic Aortic Aneurysms and Dissections
✍ Scribed by H. Pannu; V.T. Fadulu; J. Chang
- Book ID
- 113415541
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 31 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1062-1458
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Forty-three sporadic gastric cancers were analyzed with regard to whether mutations of simple repeated sequences in the transforming growth factor fi type II receptor ( T p -I / ) gene are associated with microsatellite instability (MSI) and gastric carcinogenesis. In 12 ofthe 43 cancers (28%), MSI
Alteration of transforming growth factor beta1 (TGF-beta1) type II receptor (RII) appears to cause unresponsiveness to TGF-beta1 in tumorigenic cells. Defect in the mononucleotide repeat sequence, i.e., poly A region of TGF-beta1RII gene has been reported to be related to replication error-positive
Transforming growth factor-beta (TGF-beta) is a growth modulator that inhibits the proliferation of many epithelial cells through interaction with its receptors, the type I and type II receptors (TGF-beta RI and RII) by activating their serine/threonine kinase activities. Loss of growth inhibition b