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Mutations in theSUP35gene impair nonsense-mediated mRNA decay

✍ Scribed by S. V. Chabelskaya; G. A. Zhouravleva

Book ID
110174766
Publisher
SP MAIK Nauka/Interperiodica
Year
2010
Tongue
English
Weight
416 KB
Volume
44
Category
Article
ISSN
0026-8933

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Nonsense-mediated mRNA decay (NMD) is a process of mRNA surveillance that degrades transcripts harboring a premature termination codon (PTC). Mammalian NMD was mostly studied in cultured cells so far and there was no direct evidence yet that NMD could operate in the brain. We introduced, by homologo